AustralieFrV1, Main, Exploration, bibRecord, 003998

Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345

Identifieur interne : 003998 ( Main/Exploration ); précédent : 003997; suivant : 003999

Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345

Auteurs : Robert Clarke ; Derrick Bennett ; Sarah Parish ; Sarah Lewington ; Murray Skeaff ; Simone Jpm Eussen ; Catharina Lewerin ; David J. Stott ; Jane Armitage ; Graeme J. Hankey ; Eva Lonn ; J David Spence ; Pilar Galan ; Lisette C. De Groot ; Jim Halsey ; Alan D. Dangour ; Rory Collins ; Francine Grodstein

Source :

The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2014.

RBID : PMC:4095663

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Cognition, Complexe vitaminique B (usage thérapeutique), Compléments alimentaires, Dysfonctionnement cognitif (), Dysfonctionnement cognitif (étiologie), Essais contrôlés randomisés comme sujet, Homocystéine (antagonistes et inhibiteurs), Homocystéine (sang), Humains, Hyperhomocystéinémie (diétothérapie), Hyperhomocystéinémie (physiopathologie), Hyperhomocystéinémie (sang), Médecine factuelle, Sujet âgé, Sujet âgé de 80 ans ou plus, Vieillissement.
MESH :
- antagonistes et inhibiteurs : Homocystéine.
- diétothérapie : Hyperhomocystéinémie.
- physiopathologie : Hyperhomocystéinémie.
- sang : Homocystéine, Hyperhomocystéinémie.
- usage thérapeutique : Complexe vitaminique B.
- étiologie : Dysfonctionnement cognitif.
- Adulte d'âge moyen, Cognition, Compléments alimentaires, Dysfonctionnement cognitif, Essais contrôlés randomisés comme sujet, Humains, Médecine factuelle, Sujet âgé, Sujet âgé de 80 ans ou plus, Vieillissement.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging, Cognition, Cognitive Dysfunction (etiology), Cognitive Dysfunction (prevention & control), Dietary Supplements, Evidence-Based Medicine, Homocysteine (antagonists & inhibitors), Homocysteine (blood), Humans, Hyperhomocysteinemia (blood), Hyperhomocysteinemia (diet therapy), Hyperhomocysteinemia (physiopathology), Middle Aged, Randomized Controlled Trials as Topic, Vitamin B Complex (therapeutic use).
MESH :
- chemical , antagonists & inhibitors : Homocysteine.
- chemical , blood : Homocysteine.
- blood : Hyperhomocysteinemia.
- diet therapy : Hyperhomocysteinemia.
- etiology : Cognitive Dysfunction.
- physiopathology : Hyperhomocysteinemia.
- prevention & control : Cognitive Dysfunction.
- chemical , therapeutic use : Vitamin B Complex.
- Aged, Aged, 80 and over, Aging, Cognition, Dietary Supplements, Evidence-Based Medicine, Humans, Middle Aged, Randomized Controlled Trials as Topic.

Abstract

Background: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.

Objective: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.

Design: A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based z scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE)–type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals).

Results: The domain-composite and MMSE-type global cognitive function z scores both decreased with age (mean ± SE: −0.054 ± 0.004 and −0.036 ± 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the z score differences from baseline for individual domains or for global cognitive function (z score difference: 0.00; 95% CI: −0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (z score difference: −0.01; 95% CI: −0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: −0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment.

Conclusion: Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095663

DOI: 10.3945/ajcn.113.076349
PubMed: 24965307
PubMed Central: 4095663

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn1"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn2"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn3"><sup>4</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>5</sup>
</xref>
</title>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
</author>
<author><name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name>
</author>
<author><name sortKey="Parish, Sarah" sort="Parish, Sarah" uniqKey="Parish S" first="Sarah" last="Parish">Sarah Parish</name>
</author>
<author><name sortKey="Lewington, Sarah" sort="Lewington, Sarah" uniqKey="Lewington S" first="Sarah" last="Lewington">Sarah Lewington</name>
</author>
<author><name sortKey="Skeaff, Murray" sort="Skeaff, Murray" uniqKey="Skeaff M" first="Murray" last="Skeaff">Murray Skeaff</name>
</author>
<author><name sortKey="Eussen, Simone Jpm" sort="Eussen, Simone Jpm" uniqKey="Eussen S" first="Simone Jpm" last="Eussen">Simone Jpm Eussen</name>
</author>
<author><name sortKey="Lewerin, Catharina" sort="Lewerin, Catharina" uniqKey="Lewerin C" first="Catharina" last="Lewerin">Catharina Lewerin</name>
</author>
<author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name>
</author>
<author><name sortKey="Armitage, Jane" sort="Armitage, Jane" uniqKey="Armitage J" first="Jane" last="Armitage">Jane Armitage</name>
</author>
<author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J" last="Hankey">Graeme J. Hankey</name>
</author>
<author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
</author>
<author><name sortKey="Spence, J David" sort="Spence, J David" uniqKey="Spence J" first="J David" last="Spence">J David Spence</name>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
</author>
<author><name sortKey="De Groot, Lisette C" sort="De Groot, Lisette C" uniqKey="De Groot L" first="Lisette C" last="De Groot">Lisette C. De Groot</name>
</author>
<author><name sortKey="Halsey, Jim" sort="Halsey, Jim" uniqKey="Halsey J" first="Jim" last="Halsey">Jim Halsey</name>
</author>
<author><name sortKey="Dangour, Alan D" sort="Dangour, Alan D" uniqKey="Dangour A" first="Alan D" last="Dangour">Alan D. Dangour</name>
</author>
<author><name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name>
</author>
<author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24965307</idno>
<idno type="pmc">4095663</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095663</idno>
<idno type="RBID">PMC:4095663</idno>
<idno type="doi">10.3945/ajcn.113.076349</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">002229</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002229</idno>
<idno type="wicri:Area/Pmc/Curation">002079</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002079</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001623</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001623</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003581</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003581</idno>
<idno type="wicri:Area/PubMed/Curation">003468</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003468</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003468</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003468</idno>
<idno type="wicri:Area/Ncbi/Merge">001B64</idno>
<idno type="wicri:Area/Ncbi/Curation">001B64</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001B64</idno>
<idno type="wicri:doubleKey">0002-9165:2014:Clarke R:effects:of:homocysteine</idno>
<idno type="wicri:Area/Main/Merge">003A40</idno>
<idno type="wicri:Area/Main/Curation">003998</idno>
<idno type="wicri:Area/Main/Exploration">003998</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn1"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn2"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn3"><sup>4</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>5</sup>
</xref>
</title>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
</author>
<author><name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name>
</author>
<author><name sortKey="Parish, Sarah" sort="Parish, Sarah" uniqKey="Parish S" first="Sarah" last="Parish">Sarah Parish</name>
</author>
<author><name sortKey="Lewington, Sarah" sort="Lewington, Sarah" uniqKey="Lewington S" first="Sarah" last="Lewington">Sarah Lewington</name>
</author>
<author><name sortKey="Skeaff, Murray" sort="Skeaff, Murray" uniqKey="Skeaff M" first="Murray" last="Skeaff">Murray Skeaff</name>
</author>
<author><name sortKey="Eussen, Simone Jpm" sort="Eussen, Simone Jpm" uniqKey="Eussen S" first="Simone Jpm" last="Eussen">Simone Jpm Eussen</name>
</author>
<author><name sortKey="Lewerin, Catharina" sort="Lewerin, Catharina" uniqKey="Lewerin C" first="Catharina" last="Lewerin">Catharina Lewerin</name>
</author>
<author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name>
</author>
<author><name sortKey="Armitage, Jane" sort="Armitage, Jane" uniqKey="Armitage J" first="Jane" last="Armitage">Jane Armitage</name>
</author>
<author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J" last="Hankey">Graeme J. Hankey</name>
</author>
<author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
</author>
<author><name sortKey="Spence, J David" sort="Spence, J David" uniqKey="Spence J" first="J David" last="Spence">J David Spence</name>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
</author>
<author><name sortKey="De Groot, Lisette C" sort="De Groot, Lisette C" uniqKey="De Groot L" first="Lisette C" last="De Groot">Lisette C. De Groot</name>
</author>
<author><name sortKey="Halsey, Jim" sort="Halsey, Jim" uniqKey="Halsey J" first="Jim" last="Halsey">Jim Halsey</name>
</author>
<author><name sortKey="Dangour, Alan D" sort="Dangour, Alan D" uniqKey="Dangour A" first="Alan D" last="Dangour">Alan D. Dangour</name>
</author>
<author><name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name>
</author>
<author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
</author>
</analytic>
<series><title level="j">The American Journal of Clinical Nutrition</title>
<idno type="ISSN">0002-9165</idno>
<idno type="eISSN">1938-3207</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Cognition</term>
<term>Cognitive Dysfunction (etiology)</term>
<term>Cognitive Dysfunction (prevention & control)</term>
<term>Dietary Supplements</term>
<term>Evidence-Based Medicine</term>
<term>Homocysteine (antagonists & inhibitors)</term>
<term>Homocysteine (blood)</term>
<term>Humans</term>
<term>Hyperhomocysteinemia (blood)</term>
<term>Hyperhomocysteinemia (diet therapy)</term>
<term>Hyperhomocysteinemia (physiopathology)</term>
<term>Middle Aged</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Vitamin B Complex (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cognition</term>
<term>Complexe vitaminique B (usage thérapeutique)</term>
<term>Compléments alimentaires</term>
<term>Dysfonctionnement cognitif ()</term>
<term>Dysfonctionnement cognitif (étiologie)</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Homocystéine (antagonistes et inhibiteurs)</term>
<term>Homocystéine (sang)</term>
<term>Humains</term>
<term>Hyperhomocystéinémie (diétothérapie)</term>
<term>Hyperhomocystéinémie (physiopathologie)</term>
<term>Hyperhomocystéinémie (sang)</term>
<term>Médecine factuelle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Homocysteine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Homocysteine</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Homocystéine</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hyperhomocysteinemia</term>
</keywords>
<keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Hyperhomocysteinemia</term>
</keywords>
<keywords scheme="MESH" qualifier="diétothérapie" xml:lang="fr"><term>Hyperhomocystéinémie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognitive Dysfunction</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hyperhomocystéinémie</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hyperhomocysteinemia</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cognitive Dysfunction</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Homocystéine</term>
<term>Hyperhomocystéinémie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Vitamin B Complex</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Complexe vitaminique B</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Cognition</term>
<term>Dietary Supplements</term>
<term>Evidence-Based Medicine</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Randomized Controlled Trials as Topic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cognition</term>
<term>Compléments alimentaires</term>
<term>Dysfonctionnement cognitif</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Médecine factuelle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vieillissement</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.</p>
<p><bold>Objective:</bold>
 The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.</p>
<p><bold>Design:</bold>
 A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based <italic>z</italic>
 scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE)–type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals).</p>
<p><bold>Results</bold>
: The domain-composite and MMSE-type global cognitive function <italic>z</italic>
 scores both decreased with age (mean ± SE: −0.054 ± 0.004 and −0.036 ± 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the <italic>z</italic>
 score differences from baseline for individual domains or for global cognitive function (<italic>z</italic>
 score difference: 0.00; 95% CI: −0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (<italic>z</italic>
 score difference: −0.01; 95% CI: −0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: −0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment.</p>
<p><bold>Conclusion:</bold>
 Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mayeux, R" uniqKey="Mayeux R">R Mayeux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
<author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
<author><name sortKey="Jobst, K" uniqKey="Jobst K">K Jobst</name>
</author>
<author><name sortKey="Sutton, L" uniqKey="Sutton L">L Sutton</name>
</author>
<author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name>
</author>
<author><name sortKey="Ueland, Pm" uniqKey="Ueland P">PM Ueland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
<author><name sortKey="Birks, J" uniqKey="Birks J">J Birks</name>
</author>
<author><name sortKey="Nexo, E" uniqKey="Nexo E">E Nexo</name>
</author>
<author><name sortKey="Ueland, Pm" uniqKey="Ueland P">PM Ueland</name>
</author>
<author><name sortKey="Schneede, Pm" uniqKey="Schneede P">PM Schneede</name>
</author>
<author><name sortKey="Scott, J" uniqKey="Scott J">J Scott</name>
</author>
<author><name sortKey="Molloy, A" uniqKey="Molloy A">A Molloy</name>
</author>
<author><name sortKey="Frost, C" uniqKey="Frost C">C Frost</name>
</author>
<author><name sortKey="Evans, Jm" uniqKey="Evans J">JM Evans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seshadri, S" uniqKey="Seshadri S">S Seshadri</name>
</author>
<author><name sortKey="Beiser, A" uniqKey="Beiser A">A Beiser</name>
</author>
<author><name sortKey="Selhub, J" uniqKey="Selhub J">J Selhub</name>
</author>
<author><name sortKey="Jacques, P" uniqKey="Jacques P">P Jacques</name>
</author>
<author><name sortKey="D Agostino, Rb" uniqKey="D Agostino R">RB D'Agostino</name>
</author>
<author><name sortKey="Wilson, Pw" uniqKey="Wilson P">PW Wilson</name>
</author>
<author><name sortKey="Wolf, Pa" uniqKey="Wolf P">PA Wolf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kivipelto, M" uniqKey="Kivipelto M">M Kivipelto</name>
</author>
<author><name sortKey="Annerbo, S" uniqKey="Annerbo S">S Annerbo</name>
</author>
<author><name sortKey="Hultin, J" uniqKey="Hultin J">J Hultin</name>
</author>
<author><name sortKey="Backman, L" uniqKey="Backman L">L Backman</name>
</author>
<author><name sortKey="Viitanen, M" uniqKey="Viitanen M">M Viitanen</name>
</author>
<author><name sortKey="Fratiglioni, L" uniqKey="Fratiglioni L">L Fratiglioni</name>
</author>
<author><name sortKey="Lokk, J" uniqKey="Lokk J">J Lokk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eussen, Sj" uniqKey="Eussen S">SJ Eussen</name>
</author>
<author><name sortKey="Degroot, Lc" uniqKey="Degroot L">LC deGroot</name>
</author>
<author><name sortKey="Joosten, Lw" uniqKey="Joosten L">LW Joosten</name>
</author>
<author><name sortKey="Bloo, Rj" uniqKey="Bloo R">RJ Bloo</name>
</author>
<author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
<author><name sortKey="Ueland, Pm" uniqKey="Ueland P">PM Ueland</name>
</author>
<author><name sortKey="Schneede, J" uniqKey="Schneede J">J Schneede</name>
</author>
<author><name sortKey="Blom, Hj" uniqKey="Blom H">HJ Blom</name>
</author>
<author><name sortKey="Hoefnagels, Wh" uniqKey="Hoefnagels W">WH Hoefnagels</name>
</author>
<author><name sortKey="Vanstaveren, Wa" uniqKey="Vanstaveren W">WA vanStaveren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lewerin, C" uniqKey="Lewerin C">C Lewerin</name>
</author>
<author><name sortKey="Matousek, M" uniqKey="Matousek M">M Matousek</name>
</author>
<author><name sortKey="Steen, G" uniqKey="Steen G">G Steen</name>
</author>
<author><name sortKey="Nilsson Ehle, H" uniqKey="Nilsson Ehle H">H Nilsson-Ehle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcmahon, Ja" uniqKey="Mcmahon J">JA McMahon</name>
</author>
<author><name sortKey="Green, Tj" uniqKey="Green T">TJ Green</name>
</author>
<author><name sortKey="Skeaff, M" uniqKey="Skeaff M">M Skeaff</name>
</author>
<author><name sortKey="Knight, Rf" uniqKey="Knight R">RF Knight</name>
</author>
<author><name sortKey="Mann, Jl" uniqKey="Mann J">JL Mann</name>
</author>
<author><name sortKey="Williams, Sm" uniqKey="Williams S">SM Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Durga, J" uniqKey="Durga J">J Durga</name>
</author>
<author><name sortKey="Van Boxtel, Mp" uniqKey="Van Boxtel M">MP van Boxtel</name>
</author>
<author><name sortKey="Schouten, Eg" uniqKey="Schouten E">EG Schouten</name>
</author>
<author><name sortKey="Kok, Fj" uniqKey="Kok F">FJ Kok</name>
</author>
<author><name sortKey="Jolles, J" uniqKey="Jolles J">J Jolles</name>
</author>
<author><name sortKey="Katan, Mb" uniqKey="Katan M">MB Katan</name>
</author>
<author><name sortKey="Verhoef, P" uniqKey="Verhoef P">P Verhoef</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stott, Dj" uniqKey="Stott D">DJ Stott</name>
</author>
<author><name sortKey="Macintosh, G" uniqKey="Macintosh G">G MacIntosh</name>
</author>
<author><name sortKey="Lowe, Gdo" uniqKey="Lowe G">GDO Lowe</name>
</author>
<author><name sortKey="Rumley, A" uniqKey="Rumley A">A Rumley</name>
</author>
<author><name sortKey="Mcmahon, Ad" uniqKey="Mcmahon A">AD McMahon</name>
</author>
<author><name sortKey="Langhorne, P" uniqKey="Langhorne P">P Langhorne</name>
</author>
<author><name sortKey="Tait, Rc" uniqKey="Tait R">RC Tait</name>
</author>
<author><name sortKey="Spilg, Eg" uniqKey="Spilg E">EG Spilg</name>
</author>
<author><name sortKey="Macdonald, Jb" uniqKey="Macdonald J">JB MacDonald</name>
</author>
<author><name sortKey="Macfarlane, Pw" uniqKey="Macfarlane P">PW MacFarlane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lonn, E" uniqKey="Lonn E">E Lonn</name>
</author>
<author><name sortKey="Yusuf, S" uniqKey="Yusuf S">S Yusuf</name>
</author>
<author><name sortKey="Arnold, Mj" uniqKey="Arnold M">MJ Arnold</name>
</author>
<author><name sortKey="Sheridan, P" uniqKey="Sheridan P">P Sheridan</name>
</author>
<author><name sortKey="Pogue, J" uniqKey="Pogue J">J Pogue</name>
</author>
<author><name sortKey="Micks, M" uniqKey="Micks M">M Micks</name>
</author>
<author><name sortKey="Sheridan, P" uniqKey="Sheridan P">P Sheridan</name>
</author>
<author><name sortKey="Pogue, J" uniqKey="Pogue J">J Pogue</name>
</author>
<author><name sortKey="Micks, M" uniqKey="Micks M">M Micks</name>
</author>
<author><name sortKey="Mcqueen, Mj" uniqKey="Mcqueen M">MJ McQueen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andreeva, Va" uniqKey="Andreeva V">VA Andreeva</name>
</author>
<author><name sortKey="Kesse Guyot, E" uniqKey="Kesse Guyot E">E Kesse-Guyot</name>
</author>
<author><name sortKey="Barberger Gateau, P" uniqKey="Barberger Gateau P">P Barberger-Gateau</name>
</author>
<author><name sortKey="Fezeu, L" uniqKey="Fezeu L">L Fezeu</name>
</author>
<author><name sortKey="Hercberg, S" uniqKey="Hercberg S">S Hercberg</name>
</author>
<author><name sortKey="Galan, P" uniqKey="Galan P">P Galan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, Jh" uniqKey="Kang J">JH Kang</name>
</author>
<author><name sortKey="Cook, N" uniqKey="Cook N">N Cook</name>
</author>
<author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name>
</author>
<author><name sortKey="Buring, Je" uniqKey="Buring J">JE Buring</name>
</author>
<author><name sortKey="Albert, Cm" uniqKey="Albert C">CM Albert</name>
</author>
<author><name sortKey="Grodstein, F" uniqKey="Grodstein F">F Grodstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toole, Jf" uniqKey="Toole J">JF Toole</name>
</author>
<author><name sortKey="Malinow, Mr" uniqKey="Malinow M">MR Malinow</name>
</author>
<author><name sortKey="Chambless, Le" uniqKey="Chambless L">LE Chambless</name>
</author>
<author><name sortKey="Spence, Jd" uniqKey="Spence J">JD Spence</name>
</author>
<author><name sortKey="Pettigrew, Lc" uniqKey="Pettigrew L">LC Pettigrew</name>
</author>
<author><name sortKey="Howard, Vj" uniqKey="Howard V">VJ Howard</name>
</author>
<author><name sortKey="Sides, Eg" uniqKey="Sides E">EG Sides</name>
</author>
<author><name sortKey="Wang, Ch" uniqKey="Wang C">CH Wang</name>
</author>
<author><name sortKey="Stampfer, M" uniqKey="Stampfer M">M Stampfer</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Folstein, Mf" uniqKey="Folstein M">MF Folstein</name>
</author>
<author><name sortKey="Folstein, Se" uniqKey="Folstein S">SE Folstein</name>
</author>
<author><name sortKey="Mchugh, Pr" uniqKey="Mchugh P">PR McHugh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brandt, J" uniqKey="Brandt J">J Brandt</name>
</author>
<author><name sortKey="Spencer, M" uniqKey="Spencer M">M Spencer</name>
</author>
<author><name sortKey="Folstein, Mf" uniqKey="Folstein M">MF Folstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buckwalter, Jg" uniqKey="Buckwalter J">JG Buckwalter</name>
</author>
<author><name sortKey="Crooks, Vc" uniqKey="Crooks V">VC Crooks</name>
</author>
<author><name sortKey="Petitti, Db" uniqKey="Petitti D">DB Petitti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jager, Ca" uniqKey="De Jager C">CA de Jager</name>
</author>
<author><name sortKey="Budge, Mm" uniqKey="Budge M">MM Budge</name>
</author>
<author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
<author><name sortKey="Halsey, J" uniqKey="Halsey J">J Halsey</name>
</author>
<author><name sortKey="Lewington, S" uniqKey="Lewington S">S Lewington</name>
</author>
<author><name sortKey="Lonn, E" uniqKey="Lonn E">E Lonn</name>
</author>
<author><name sortKey="Armitage, J" uniqKey="Armitage J">J Armitage</name>
</author>
<author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name>
</author>
<author><name sortKey="B Naa, Kh" uniqKey="B Naa K">KH Bønaa</name>
</author>
<author><name sortKey="Spence, Jd" uniqKey="Spence J">JD Spence</name>
</author>
<author><name sortKey="Nyg Rd, O" uniqKey="Nyg Rd O">O Nygǻrd</name>
</author>
<author><name sortKey="Jamison, R" uniqKey="Jamison R">R Jamison</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Armitage, P" uniqKey="Armitage P">P Armitage</name>
</author>
<author><name sortKey="Berry, G" uniqKey="Berry G">G Berry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wald, Ds" uniqKey="Wald D">DS Wald</name>
</author>
<author><name sortKey="Kasturiratne, A" uniqKey="Kasturiratne A">A Kasturiratne</name>
</author>
<author><name sortKey="Simmonds, M" uniqKey="Simmonds M">M Simmonds</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, Ah" uniqKey="Ford A">AH Ford</name>
</author>
<author><name sortKey="Almeida, Op" uniqKey="Almeida O">OP Almeida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Norman, Gr" uniqKey="Norman G">GR Norman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Da Costa, Br" uniqKey="Da Costa B">BR da Costa</name>
</author>
<author><name sortKey="Nuesch, E" uniqKey="Nuesch E">E Nuesch</name>
</author>
<author><name sortKey="Ruties, Aw" uniqKey="Ruties A">AW Ruties</name>
</author>
<author><name sortKey="Johnston, Bc" uniqKey="Johnston B">BC Johnston</name>
</author>
<author><name sortKey="Reichenbach, S" uniqKey="Reichenbach S">S Reichenbach</name>
</author>
<author><name sortKey="Trelle, S" uniqKey="Trelle S">S Trelle</name>
</author>
<author><name sortKey="Guyatt, Gh" uniqKey="Guyatt G">GH Guyatt</name>
</author>
<author><name sortKey="Juni, P" uniqKey="Juni P">P Juni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aisen, Ps" uniqKey="Aisen P">PS Aisen</name>
</author>
<author><name sortKey="Schneider, Ls" uniqKey="Schneider L">LS Schneider</name>
</author>
<author><name sortKey="Sano, M" uniqKey="Sano M">M Sano</name>
</author>
<author><name sortKey="Diaz Arrastia, R" uniqKey="Diaz Arrastia R">R Diaz-Arrastia</name>
</author>
<author><name sortKey="Van Dyck, Ch" uniqKey="Van Dyck C">CH van Dyck</name>
</author>
<author><name sortKey="Weiner, Mf" uniqKey="Weiner M">MF Weiner</name>
</author>
<author><name sortKey="Bottiglieri, T" uniqKey="Bottiglieri T">T Bottiglieri</name>
</author>
<author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name>
</author>
<author><name sortKey="Stokes, Kt" uniqKey="Stokes K">KT Stokes</name>
</author>
<author><name sortKey="Thomas, Rg" uniqKey="Thomas R">RG Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walker, Jg" uniqKey="Walker J">JG Walker</name>
</author>
<author><name sortKey="Batterham, Pj" uniqKey="Batterham P">PJ Batterham</name>
</author>
<author><name sortKey="Mackinnon, Aj" uniqKey="Mackinnon A">AJ Mackinnon</name>
</author>
<author><name sortKey="Jorm, Af" uniqKey="Jorm A">AF Jorm</name>
</author>
<author><name sortKey="Hickie, I" uniqKey="Hickie I">I Hickie</name>
</author>
<author><name sortKey="Fenech, M" uniqKey="Fenech M">M Fenech</name>
</author>
<author><name sortKey="Kljakovic, M" uniqKey="Kljakovic M">M Kljakovic</name>
</author>
<author><name sortKey="Crisp, D" uniqKey="Crisp D">D Crisp</name>
</author>
<author><name sortKey="Christensen, H" uniqKey="Christensen H">H Christensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jager, Ca" uniqKey="De Jager C">CA de Jager</name>
</author>
<author><name sortKey="Oulhaj, A" uniqKey="Oulhaj A">A Oulhaj</name>
</author>
<author><name sortKey="Jacoby, R" uniqKey="Jacoby R">R Jacoby</name>
</author>
<author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name>
</author>
<author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, Ah" uniqKey="Ford A">AH Ford</name>
</author>
<author><name sortKey="Flicker, L" uniqKey="Flicker L">L Flicker</name>
</author>
<author><name sortKey="Alfonso, H" uniqKey="Alfonso H">H Alfonso</name>
</author>
<author><name sortKey="Thomas, J" uniqKey="Thomas J">J Thomas</name>
</author>
<author><name sortKey="Clarnette, R" uniqKey="Clarnette R">R Clarnette</name>
</author>
<author><name sortKey="Martins, R" uniqKey="Martins R">R Martins</name>
</author>
<author><name sortKey="Almeida, Op" uniqKey="Almeida O">OP Almeida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vollset, Se" uniqKey="Vollset S">SE Vollset</name>
</author>
<author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
<author><name sortKey="Lewington, S" uniqKey="Lewington S">S Lewington</name>
</author>
<author><name sortKey="Ebbing, M" uniqKey="Ebbing M">M Ebbing</name>
</author>
<author><name sortKey="Halsey, J" uniqKey="Halsey J">J Halsey</name>
</author>
<author><name sortKey="Lonn, E" uniqKey="Lonn E">E Lonn</name>
</author>
<author><name sortKey="Armitage, J" uniqKey="Armitage J">J Armitage</name>
</author>
<author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name>
</author>
<author><name sortKey="Hankey, Gj" uniqKey="Hankey G">GJ Hankey</name>
</author>
<author><name sortKey="Spence, Jd" uniqKey="Spence J">JD Spence</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spence, Jd" uniqKey="Spence J">JD Spence</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Radimer, K" uniqKey="Radimer K">K Radimer</name>
</author>
<author><name sortKey="Bindewald, B" uniqKey="Bindewald B">B Bindewald</name>
</author>
<author><name sortKey="Hughes, Eb" uniqKey="Hughes E">EB Hughes</name>
</author>
<author><name sortKey="Swanson, C" uniqKey="Swanson C">C Swanson</name>
</author>
<author><name sortKey="Picciano, Mf" uniqKey="Picciano M">MF Picciano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henderson, L" uniqKey="Henderson L">L Henderson</name>
</author>
<author><name sortKey="Gregory, J" uniqKey="Gregory J">J Gregory</name>
</author>
<author><name sortKey="Swan, G" uniqKey="Swan G">G Swan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
<author><name sortKey="Smith, Sm" uniqKey="Smith S">SM Smith</name>
</author>
<author><name sortKey="De Jager, Ca" uniqKey="De Jager C">CA de Jager</name>
</author>
<author><name sortKey="Whitbread, P" uniqKey="Whitbread P">P Whitbread</name>
</author>
<author><name sortKey="Johnston, C" uniqKey="Johnston C">C Johnston</name>
</author>
<author><name sortKey="Agacinski, G" uniqKey="Agacinski G">G Agacinski</name>
</author>
<author><name sortKey="Oulhaj, A" uniqKey="Oulhaj A">A Oulhaj</name>
</author>
<author><name sortKey="Bradley, Km" uniqKey="Bradley K">KM Bradley</name>
</author>
<author><name sortKey="Jacoby, R" uniqKey="Jacoby R">R Jacoby</name>
</author>
<author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Douaud, G" uniqKey="Douaud G">G Douaud</name>
</author>
<author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name>
</author>
<author><name sortKey="Dejager, Ca" uniqKey="Dejager C">CA deJager</name>
</author>
<author><name sortKey="Jacoby, R" uniqKey="Jacoby R">R Jacoby</name>
</author>
<author><name sortKey="Nichols, Te" uniqKey="Nichols T">TE Nichols</name>
</author>
<author><name sortKey="Smith, Se" uniqKey="Smith S">SE Smith</name>
</author>
<author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name>
</author>
<author><name sortKey="Bennett, D" uniqKey="Bennett D">D Bennett</name>
</author>
<author><name sortKey="Parish, S" uniqKey="Parish S">S Parish</name>
</author>
<author><name sortKey="Verhoef, P" uniqKey="Verhoef P">P Verhoef</name>
</author>
<author><name sortKey="Dotsch Klerk, M" uniqKey="Dotsch Klerk M">M Dötsch-Klerk</name>
</author>
<author><name sortKey="Lathrop, M" uniqKey="Lathrop M">M Lathrop</name>
</author>
<author><name sortKey="Xu, P" uniqKey="Xu P">P Xu</name>
</author>
<author><name sortKey="Nordestgaard, Bg" uniqKey="Nordestgaard B">BG Nordestgaard</name>
</author>
<author><name sortKey="Holm, H" uniqKey="Holm H">H Holm</name>
</author>
<author><name sortKey="Hopewell, Jc" uniqKey="Hopewell J">JC Hopewell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grarup, N" uniqKey="Grarup N">N Grarup</name>
</author>
<author><name sortKey="Sulem, P" uniqKey="Sulem P">P Sulem</name>
</author>
<author><name sortKey="Sandholt, Ch" uniqKey="Sandholt C">CH Sandholt</name>
</author>
<author><name sortKey="Thorleifsson, G" uniqKey="Thorleifsson G">G Thorleifsson</name>
</author>
<author><name sortKey="Ahluwalia, Ts" uniqKey="Ahluwalia T">TS Ahluwalia</name>
</author>
<author><name sortKey="Steinthorsdottir, V" uniqKey="Steinthorsdottir V">V Steinthorsdottir</name>
</author>
<author><name sortKey="Bjarnason, H" uniqKey="Bjarnason H">H Bjarnason</name>
</author>
<author><name sortKey="Gudbjartsson, D" uniqKey="Gudbjartsson D">D Gudbjartsson</name>
</author>
<author><name sortKey="Magnusson, O" uniqKey="Magnusson O">O Magnusson</name>
</author>
<author><name sortKey="Spars, T" uniqKey="Spars T">T Sparsø</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Armitage, Jane" sort="Armitage, Jane" uniqKey="Armitage J" first="Jane" last="Armitage">Jane Armitage</name>
<name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name>
<name sortKey="Dangour, Alan D" sort="Dangour, Alan D" uniqKey="Dangour A" first="Alan D" last="Dangour">Alan D. Dangour</name>
<name sortKey="De Groot, Lisette C" sort="De Groot, Lisette C" uniqKey="De Groot L" first="Lisette C" last="De Groot">Lisette C. De Groot</name>
<name sortKey="Eussen, Simone Jpm" sort="Eussen, Simone Jpm" uniqKey="Eussen S" first="Simone Jpm" last="Eussen">Simone Jpm Eussen</name>
<name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
<name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
<name sortKey="Halsey, Jim" sort="Halsey, Jim" uniqKey="Halsey J" first="Jim" last="Halsey">Jim Halsey</name>
<name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J" last="Hankey">Graeme J. Hankey</name>
<name sortKey="Lewerin, Catharina" sort="Lewerin, Catharina" uniqKey="Lewerin C" first="Catharina" last="Lewerin">Catharina Lewerin</name>
<name sortKey="Lewington, Sarah" sort="Lewington, Sarah" uniqKey="Lewington S" first="Sarah" last="Lewington">Sarah Lewington</name>
<name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
<name sortKey="Parish, Sarah" sort="Parish, Sarah" uniqKey="Parish S" first="Sarah" last="Parish">Sarah Parish</name>
<name sortKey="Skeaff, Murray" sort="Skeaff, Murray" uniqKey="Skeaff M" first="Murray" last="Skeaff">Murray Skeaff</name>
<name sortKey="Spence, J David" sort="Spence, J David" uniqKey="Spence J" first="J David" last="Spence">J David Spence</name>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003998 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003998 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4095663
   |texte=   Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24965307" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345

Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.